When radiation misfires...literally

The New York Times has a rather chilling account of how radiation overdose in the treatment of some cancer patients caused deadly side effects leading to death. The entire sobering article deserves to be read. In one case a man's tongue was going to be selectively irradiated; instead his whole face received a blast of radiation that led to a horrible, slow death. His story makes for very painful reading. In another case, misguided radiation beams literally cut out a hole in a woman's chest that gradually killed her.

And all this mainly because of computer errors that were not detected by human beings, errors that caused the radiation to be overdosed or misdirected. Seems like one of those classic "technology is a double-edged sword" kind of scenarios with the whole system just becoming too complex for human understanding. In one instance, a wedge in a linear accelerator delivering the radiation was supposed to focus the beam in the "in" position. But the computer that used Varian software- the same software that I used in grad school for operating the NMR spectrometer built by the same company- made a mistake and instead pivoted the wedge to the "out" position, removing the radiation shielding. The mistake was not detected 27 times, leading to acute radiation overdoses in the wrong parts of the body. In the case of the man whose tongue was supposed to be treated, an error in the software failed to save the critical settings for the accelerator which would have focused the radiation to the right parts.

The statistics unearthed by the Times are startling. From 2001 to 2009, more than 600 cases of improper radiation treatment were reported. Out of those, 255 were related to an overdose, while 284 were related to the wrong parts of the body being exposed to radiation. Even in its idealized form radiation has side-effects, so one would assume that doctors and technicians would be deathly serious about operating these protocols. These statistics were collected for New York State, which is apparently supposed to have some of the strictest radiation standards in the country.

What is even more shocking is the lack of transparency due to "privacy laws". Names of the culprits have been withheld, and some of them seem to have been let off the hook with a simple reprimand. Some doctors who have participated in the treatments refused to talk to the journalists. There also does not seem to be a single agency responsible for these radiation safeguards. On top of it all there seem to be scant ways for patients to pick beforehand which hospital they would like to receive radiation treatment in, since records of mistakes are not available to the public. The whole shebang sounds appalling.

Now I understand that 600 cases in 8 years is probably peanuts compared to the total number of cases in which radiation has worked successfully. Nonetheless, the factors responsible for the lapses and the horrendous consequences deserve scrutiny (seriously, death due to "computer error" sounds like something out of a bad science fiction horror movie). For something as serious as radiation treatment for cancer, one would assume that the same kinds of safeguards, fail-safe mechanisms and backup checks would be in place as are used in nuclear reactor safety. Yet it seems that shoddy training, computer error, and lack of accountability are dealing out death and enormous physical and psychological suffering to patients and their families.

THE OPEN SOCIETY

I am having a fantastic time in London. Details later, but what struck me the most was the incredibly encouraging friendliness, helpfulness, and most importantly open-mindedness of everyone we met. A large group of people whom we met consisted of doctors and clinicians who are directly involved with cancer patients. I was surprised and very happy to see that these people, with little to no experience with organic synthesis or molecular modeling, were extremely open to collaboration including both these disciplines.

This is exactly the kind of culture we need to see to fight cancer and other ailments, where everyone from doctors to modelers to synthesists to materials scientists and engineers seamlessly work together and are open to collaboration. Also, nobody but a doctor can truly understand what impact a new treatment can have on a disease. One of the doctors we met had just seen a patient, a young lady not more than 35. He told us that he did not expect her to live much longer. Faced with morbid scenarios like this on a regular basis, it should not be surprising if doctors are willing to try anything and everything to make a new treatment available to patients. And yet it is rare to find people having an untrammeled vision of collaboration, which made our experience a truly pleasant and encouraging one.

This sort of reminds me in a different sense of that saying which says that strangers are simply family members who we have yet to meet.